Effect of Toxicity Cypermethrin in Animals: A Review
Keywords:
Cypermethrin, Toxicity, Mode of Action, half-life, Biochemical and Hematological Effects and ResiduesAbstract
Despite significant worries about the widespread use of cypermethrin in veterinary, agricultural, and insecticidal applications, there is solid evidence of cypermethrin toxicity for humans. Cypermethrin is a synthetic parathyroid that is catastrophic and for which there is yet no antidote for poisoning. The cypermethrin exposure affects the sodium channel, magnesium, and Apse in the human body. In addition to having neurotoxic effects, cypermethrin also has hepatotoxic effects that cause microtonal enzymes in the liver. Although cypermethrin seems to be more tolerable to animals than to humans, it is nonetheless harmful whether it is ingested or used directly. In this work, we evaluated the existing body of knowledge on the neurotoxicity of cypermethrin and its effects on behavior, molecular level, and reproductive system in humans and animals.
References
Roberts,N.L.(1987).Tissue residues of cypermethrin following topical administration of cypermethrin pour-on formulation SF06646 to calves .SLL 97/86/86178 .
EMEA(European Agency for the Evaluation of Medical products )(1998).Cypermethrin, summary report(1).EMEA/MRL/403/98-Final.www.emea.eu.int .
EMEA (European Agency for the Evaluation of Medical products) (2003).Cypermethrin summary report(1).EMEA/MRL/876/03-Final.www.emea.eu.int .
EMEA(European Agency for the Evaluation of Medical products ) (2004).Cypermethrin summary report (1).EMEA/MRL/890/04-Final.www.emea.eu.int
Sudakin,D.L.(2006). Pyrethroid insecticide : advances and challenges in biomonitoring . Clin. Toxicol. 44:31-37 .
USEPA (United State Environment Protection Agency)(2010). Cypermethrin (CASRN 52315-07-8) . http://www.epa.gov/iris/subst/0380.htm .
Harlod, E. ; James, A. ; Doglas, C. ; Cherly, L. ; Franklin, M. and Glenn, H.(2003). The merck veterinary manual , Merck & CO., Inc. Rahaway. N.j., U.S.A. 9th ed .
Yilmaz,S.N.;Comelekoglu,U.; Koscun,B.; Balli,E. and Ozge,A.(2008).Effects of cypermethrin on isolated frog sciatic nerve:an ultrastructural study. Turk.J. Med. Sci.38(2):121-125
JECFA.(1997).Residues of some veterinary drugs in animals and food . FAO food and nutrition paper 41/9 .
JECFA.(2000).Residues of some veterinary drugs in animals and food . FAO food and nutrition paper 41/13.
Wefco.(1989).Cypermethrin.South Africa, www.wefco.za .
WHO, (1989). Environmental Health Criteria, Cypermethrin. World Health Organization, Scientific Publication No. 82, pp 11-17, Geneva.
WHO.(1997). Recommended classification of pesticides by hazared 1996-1997,class II.UN.
WHO(1996). The WHO recommended classification of pesticides by hazard and guidelines to classification 1996-1997 (WHO/PCS/96.3).Available from international programs on chemical safety ,
Cox, C. (1996). Cypermethrin . J. of Pesti. .16 ( 2): 15 – 20.
Tamang, R.K.;Jha,G.J. and Singh,K.K.(1991).Clinico- pathology of acute cypermethrin toxicity in goats .Indian J. Anim. Sci.61:493-499
Tample ,W.A. and Smith,N.A.(1996). Cypermethrin. Environmental Potential Agency .E-mail wtemple@gandalf.otago.ac.nz .
Yousef ,M.I.; Ibrahim, H.Z.; Yacout ,M.H.M. and Hassan,A.(1998) Effect of cypermethrin and dimethoate, on some physiological and biochemical parameters in Barky sheep. Egyptian J. Nutr. Feeds . 1:41-52.
Heamza,D.J.(2006).Chemical and histological study of Effect of some Organo Phosphorus Compounds On Nervous System in Adult Hens .B.V.M.S. collage of vet. Med. .Basrah university .
Yousef ,M.I.; Abbassi, M.;Sand Yacout, M.H.M.(1999). Assessment of cypermethrin and dimethoate toxicity in Barky sheep, Biochemical and histological changes and tissue residues. Egyptian J. Anim. Prod .36:25-41.
Khan,A.;Faridi,H.A.M.;Ali,m.;Khan,M.Z.;Siddique,M.Hussain,I.and Ahmad,M.(2009).Effects of cypermethrin on clinicohemato-biochemical and pathological parameters in male Dwarf goats (Capra hircus).J.Exp. Toxicol. Pathol. 61(2):151-160
Harlod, E. ; James, A. ; Doglas, C. ; Cherly, L. ; Franklin, M. and Glenn, H.(2003). The merck veterinary manual , Merck & CO., Inc. Rahaway. N.j., U.S.A. 9th ed .
Hill,S.E.; Omme,B.R. and Choi,A.H.(2010). PAN pesticide database , pesticide action network, North Amarica (San Fransisco.C.A.).http:www.pesticideinfo.org.
Dorman ,D.C. and Beasley ,V.R.(1991).Neurotoxicology of pyrethrin and the pyrethroid insecticides .J. Vet. Hum. Toxicol.33(3):238-243 .
Seth, P. K.; Jaffery, F. N. and Khana, V. k. (2000). Toxicology .Indian Journal of pharmacology. 32: 134-151.
Tucker S.B.;FlanniganS.A. and Ross C.E.(1984) Inhibitions of Cutaneous paresthesia resulting from synthetic pyrethroid exposure .Int.J.DErmatol.10:686-689 .
Kol,I.O.;gursoy,S.;Kaygusuz,K.;Bagcivan,I. and Mimaraglu,C. (2007). Intramuscular injection of co-formulated organophosphate and synthetic pyrethroid : acase report.Clinic.Pract.Rev.;8:298-292 .
Adriana, F.S.(2004).Residues of some veterinary drugs / Cypermethrin .Food and Agriculture Organization , 1st edition , United Nation .Pp:16 – 23 .
Smith ,N.A. ; Manter , K.O. and Franki ,S.G.(1996).Cypermethrin .Vet. Med. J. (9): 32-41 .
Beyerbach,A.(2000).C-cypermethrin :Absorption ,distribution , metabolism and excretion in sheep . Covance laboratories,Report no. 1412/021-D1141,Sponsor submitted .
Khanna R.N.; Gupta,G.S.D. and Anand ,M. (2002).Kinetics and distribution of cypermethrin in blood, brain , and spinal cord after single administration to rabbits . Bull. Environ. Contam.Toxicol. 69:749-755 .
Valez,R.T.; Xue,J.; Scollon,E.; Star,J.; Egeghy,P.; Barr,D.;Deveto,M. and Dary,C.(2008).Dietary exposure to pyrethroid in the US population.USEPA .
Iwanika,B.N. and Borzecki,A.(2008). Effect of cypermethrin on memory ,movement activity and co-crdination in mice after transient incomplete cerebral ischemia .Pharmacological report,60:699-705 .
Atamanalp,M;Keles,M.S.;and Aras,H.I.(2002).The effects of cypermethrin (A Synthatic pyrethroid) on some biochemical parameters (Ca,P,Na and TP) of Rainbow trout (Oncorhynchus mykiss).Turk J. Vet.Anim. Sci.26:1157-1160 .
Woolen, B.H.; Marsh,J.R.; Laird,W.J.D. and Lesser J.E.(1992).The metabolism of cypermethrin in man:differences in urinary metabolitec profiles following oral and dermal administration .Xenobiotica,22(8): 983-991 .
Jagvinder,K.;Sanhu,H.S.and Kaur,J.(2001).Subacute oral toxicity of cypermethrin and deltamethrin in buffalo calves . Indian J. Anim. Sci. 71:1150-1152 .
He,F.; Wang,S.; Liu,L.; Chen,S.; Zhang,Z. and Sun,J.(1989).Clinical manifestation and diagnosis of acute pyrethroid poisoning .Arch.Toxicol. 63:58-59
Venkateshwaralu, P.; Sharma,B.J.R.; Kala Kumar,B.; Reddy,K.S. and Revi Kumar ,P. (1997). Comparative evaluation of toxicity of carbaryl,cypermethrin and malathion on testes in mice.Indian J. Toxicol. 4:33-37 .
Ecobichan,D.J.(1991).Toxic effects of pesticides. in Casarett and Doull's Toxicology,The Basic Science of Poisons, Third Edition. Macmallin Publishing Company, NY .
EPA(1998).Cypermethrin Pesticide Petition filling 3/98. Fedral register 63(53):13404-13409 .
Amelotti,I.;Catala,S.S. and Gorla,D.E.(2009).Response of Triatoma infestans to pour –on cypermethrin applied to chickens under laboratory conditions .Men. Oswaldo Cruz.,Riode Janero.140(3):481-485 .
SEPA,EA(Scottish Environment Protection Agency) and VMD.(2006).Use of Cypermethrin sheep dip products following suspension of their marketing authorizations. Public notice July2006. http://www.vmd.gov.uk/general/sheepdip/publicnotice.pdf?lang
FMC ( 2003).Material safety data sheet . Cynoff WP Insecticide .http://msds.fmc.com/msds/3469IHPH.HTM .
Yilmaz,M.; Gül,A. and Erbaslik.(2004).acute toxicity of alphacypermethrin to guppy ( Poecilia reteculata,Pollas,1859 ) .J. chemosphere 56: 381-385 .
Shah,M.K.;Khan,A.;Rizvi,F.;Sidddique,M. and Ur-Rahman,S. .(2007). Effect of cypermethrin on clinico-haematological parameters .pak. Vet. J. .27(4):171-175 .
Hayes,W.J.and Laws,E.R.(1990).Hand book of pesticide toxicology, Classes of pesticides.Vol.3.Academic press, Inc.,NY.
Chapman ,P.A.; Webb, D.P. and Walker, S.J. .(1993). The potential of some newer photo stable pyrethroid to select for resistance in the housefly Musca domistca , BULL. Entom. Res.:.517-521 .
IPCS.(1995).Summary of toxicological evaluation performed by joint meeting on pesticide residues (JMPR)
Shafer,T.J.; Meyer,D.A. and Crofton,K.M. (2005).Development neurotoxicity of pyrethroid insecticides :Critical review and future research needs . Environ. Hlth. Persp 113:123-136 .
Wikipedia.(2010).http://www.en.wikipedia.org/wiki/cypermethrin
Ray,D.E. (2007).Pyrethroid insecticides :mechanisms of toxicity systemic poisoning syndromes ,paresthesia, and therapy
Mehhorn,H.; Schmahl,G.; D'Haese,J. and Schmacher,B. (2007).Deltamethrin treatment of sheep and cattle : Pilot study of killing effects on Culicoides species (Ceratopogonidae) Parasitology Research.Institute health, UK .
Flannigan ,S.A.;Tucker,S.B. and Key,M.M.(1985).Synthetic pyrethroid insecticides:A dermatological evaluation .Br.J.Ind.Med.42:363-372.
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