Virus Structure and The Hypotheses Regarding Their Origin
Keywords:
Virus structure, virus vrigin hypotheses, virus evolution, capsid, nucleic acid, viral genome, giant viruses, regressive hypothesis, progressive hypothesis, virus-first hypothesis.Abstract
This paper explores the structural organization of viruses and the primary hypotheses regarding their origin. Viruses are acellular entities composed of a nucleic acid genome enclosed by a protein capsid, and sometimes a lipid envelope. Their structural simplicity belies a remarkable ability to infect and replicate within host cells. The article reviews three main theories of viral origin: the regressive hypothesis, suggesting viruses evolved from degenerate cells; the progressive hypothesis, proposing an origin from mobile genetic elements; and the virus-first hypothesis, asserting that viruses co-evolved with or even predated cellular life. The discovery of giant viruses has challenged traditional views and suggests a more complex evolutionary history. The paper concludes that while the origin of viruses remains uncertain, their impact on evolution, ecology, and biotechnology is profound and ongoing.
References
Bamford, D. H., & Grimes, J. M. (2003). Evolution of viruses. Virus Research, 92(1), 1-16.
Koonin, E. V., & Dolja, V. V. (2013). Evolution and taxonomy of viruses: On the origins of viruses and their genomes. Research in Microbiology, 164(5), 347-358.
Raoult, D., & Forterre, P. (2008). Redefining viruses: Lessons from mimivirus. Nature Reviews Microbiology, 6(4), 315-317.
Williams, R. (2006). The evolution of viruses: From cellular parasites to emerging agents of disease. BioEssays, 28(8), 748-756.
Viruses and their evolution. (2019). Annual Review of Virology, 6, 21-35.