Surfactant Therapy in Premature Infants: A Critical Tool in Neonatal Care
Keywords:
Respiratory distress syndrome (RDS), very low birth weight (VLBW), Incidence of Bronchopulmonary Dysplasia (BPD), Oxygen Saturation and Blood Gas Levels, Surfactant proteins (SP-A and SP-D), neonatal intensive care unit (NICU), randomized controlled trial (RCT).Abstract
Premature birth is a major contributor to neonatal morbidity and mortality, with respiratory distress syndrome (RDS) representing one of the most critical complications. Surfactant therapy has revolutionized the management of RDS in preterm infants, significantly improving survival and reducing pulmonary complications. This article reviews the physiology of surfactant, the pathophysiology of RDS, the types of surfactant preparations available, administration techniques, timing of therapy, and current best practices.
References
Polin RA, Carlo WA. Surfactant Replacement Therapy for Preterm and Term Neonates With Respiratory Distress. Pediatrics. 2014.
Sweet DG, et al. European Consensus Guidelines on the Management of Respiratory Distress Syndrome – 2022 Update. Neonatology.
Jobe AH, Ikegami M. Mechanisms Initiating Lung Injury in the Preterm. Early Hum Dev. 1998.
Mead, J., and Avery, M. E. (1959). Surface characteristics in connection with hyaline membrane illness and atelectasis. AMA Children's Diseases Journal, 97(5), 517-523.
Ikegami, M., and Jobe, A. H. (1998). mechanisms that cause lung damage in premature infants. 53(1), 81-94; Early Human Development.
Richmond, P., Simmer, K., Strunk, T., Currie, A., & Burgner, D. (2011). Human newborns with innate immunity: preterm is more than just immaturity. 24(1), 25–31; Journal of Maternal-Fetal & Neonatal Medicine.
Moss, T. J. M., and Melville, J. M. (2013). the effects of premature birth on the immune system. Neuroscience Frontiers, 7, 79.
Ballard, R. A., and P. L. Ballard (1995). Prenatal glucocorticoid use: scientific foundation and treatment plans. 173(1), 254-262, American Journal of Obstetrics and Gynaecology.
Morley, C. J., and R. F. Soll (2001). Using surfactant prophylactically as opposed to selectively can help reduce morbidity and death in premature babies. Database of Systematic Reviews, Cochrane, 2.
